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With collaboration of Dr. Lucky Jain, Consulting Editor, Dr. Caplan has assembled articles devoted to the most current clinical advances in necrotizing enterocolitis. He has invited expert authors from top institutions to contribute timely reviews on the following topics: Biomarker Discovery: New markers that improve early diagnostic capability; Probiotics: State of the art; NEC Pathophysiology: How microbiome data alters our understanding; Effect of Human Milk on NEC; Influence of Growth Factors on the Development of NEC; Can Fish Oil Reduce the Incidence of NEC by Altering the Inflammatory Response; Oral Mother’s Milk: State of the art and influence on NEC; Does Surgical Management Alter the Outcome of NEC; Epidemiology of NEC: New considerations and influence of PRBC transfusions and anemia; Role of Abdominal Ultrasound in Diagnosis of NEC; and Modifiable Risk Factors in NEC: 2018. Readers will come away with the scientific and medical information they need to make clinical decisions to improve patient outcomes.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. CME Accreditation Page - p. xi 7. Forthcoming Issues - p. xiii 8. Foreword - p. xv 9. Preface - p. xvii 10. Biomarker Discovery and Utility in Necrotizing Enterocolitis - p. 1 11. Challenges in Advancing Necrotizing Enterocolitis Research - p. 19 12. Necrotizing Enterocolitis Pathophysiology: How Microbiome Data Alter Our Understanding - p. 29 13. Closing the Gap Between Recommended and Actual Human Milk Use for Fragile Infants: What Will It Take to Overcome Disparities? - p. 39 14. Influence of Growth Factors on the Development of Necrotizing Enterocolitis - p. 51 15. Can Fish Oil Reduce the Incidence of Necrotizing Enterocolitis by Altering the Inflammatory Response? - p. 65 16. Oropharyngeal Mother’s Milk: State of the Science and Influence on Necrotizing Enterocolitis - p. 77 17. Does Surgical Management Alter Outcome in Necrotizing Enterocolitis? - p. 89 18. Epidemiology of Necrotizing Enterocolitis: New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia - p. 101 19. Role of Abdominal US in Diagnosis of NEC - p. 119 20. Modifiable Risk Factors in Necrotizing Enterocolitis - p. 129 21. Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science - p. 145

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With collaboration of Dr. Lucky Jain, Consulting Editor, Dr. Caplan has assembled articles devoted to the most current clinical advances in necrotizing enterocolitis. He has invited expert authors from top institutions to contribute timely reviews on the following topics: Biomarker Discovery: New markers that improve early diagnostic capability; Probiotics: State of the art; NEC Pathophysiology: How microbiome data alters our understanding; Effect of Human Milk on NEC; Influence of Growth Factors on the Development of NEC; Can Fish Oil Reduce the Incidence of NEC by Altering the Inflammatory Response; Oral Mother’s Milk: State of the art and influence on NEC; Does Surgical Management Alter the Outcome of NEC; Epidemiology of NEC: New considerations and influence of PRBC transfusions and anemia; Role of Abdominal Ultrasound in Diagnosis of NEC; and Modifiable Risk Factors in NEC: 2018. Readers will come away with the scientific and medical information they need to make clinical decisions to improve patient outcomes.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. CME Accreditation Page - p. xi 7. Forthcoming Issues - p. xiii 8. Foreword - p. xv 9. Preface - p. xvii 10. Biomarker Discovery and Utility in Necrotizing Enterocolitis - p. 1 11. Challenges in Advancing Necrotizing Enterocolitis Research - p. 19 12. Necrotizing Enterocolitis Pathophysiology: How Microbiome Data Alter Our Understanding - p. 29 13. Closing the Gap Between Recommended and Actual Human Milk Use for Fragile Infants: What Will It Take to Overcome Disparities? - p. 39 14. Influence of Growth Factors on the Development of Necrotizing Enterocolitis - p. 51 15. Can Fish Oil Reduce the Incidence of Necrotizing Enterocolitis by Altering the Inflammatory Response? - p. 65 16. Oropharyngeal Mother’s Milk: State of the Science and Influence on Necrotizing Enterocolitis - p. 77 17. Does Surgical Management Alter Outcome in Necrotizing Enterocolitis? - p. 89 18. Epidemiology of Necrotizing Enterocolitis: New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia - p. 101 19. Role of Abdominal US in Diagnosis of NEC - p. 119 20. Modifiable Risk Factors in Necrotizing Enterocolitis - p. 129 21. Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science - p. 145

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