Continuing in the rich tradition of this popular handbook series, The Washington Manual® of Hematopathology provides concise, high-yield content that reflects today’s fast-changing advances in the field. Edited by Drs. Brooj Abro, John L. Frater, Louis P. Dehner, John D. Pfeifer, and Anjum Hassan, this all-new volume focuses on the essential information you need to know, using a concise format, along with numerous figures, tables, algorithms, and images throughout. In one convenient, portable resource, you’ll find complete coverage of hematopathology—both benign and malignant entities—all at your fingertips for quick review and reference.
1. I Introduction to Hematopathology - p. xii 2. 1. Normal Anatomy - p. 1 3. 1.1 Blood, Bone Marrow, and Thymus - p. 1 4. 1.2 Lymph Node - p. 10 5. 1.3 Spleen - p. 15 6. 2. Approach to the Bone Marrow and Lymph Node Biopsy - p. 18 7. 3. Approach to Fine Needle Aspiration of Hematologic Malignancies - p. 24 8. II Non-neoplastic - p. 31 9. 4. Peripheral blood - p. 32 10. 4.1: Red Blood Cell Disorders - p. 32 11. 4.2: White Blood Cell Disorders - p. 44 12. 4.3: Platelet Disorders - p. 53 13. 5. Bone marrow - p. 68 14. 5.1 Bone Marrow Abnormalities in Systemic Conditions - p. 68 15. 5.2 Bone Marrow Failure Syndromes - p. 77 16. 6. Lymph node - p. 84 17. 6.1: Reactive Lymphoid Hyperplasia and Benign Noninfectious Lymphadenopathies - p. 84 18. 6.2 Infectious Lymphadenopathies - p. 95 19. 7. Spleen - p. 107 20. 7.1 Nonneoplastic Disorders of the Spleen - p. 107 21. 7.2 Non-hematopoietic Tumors and Tumor-Like Lesions of the Spleen - p. 112 22. III Neoplastic - p. 115 23. Part 1: Myeloid Neoplasms - p. 115 24. 8. Overview and Classification of Myeloid Neoplasms - p. 116 25. 9. Myeloproliferative Neoplasms - p. 130 26. 10. Myeloid Precursor Lesions and Myelodysplastic Syndromes/Neoplasms - p. 149 27. 11. Myelodysplastic/Myeloproliferative Neoplasms - p. 164 28. 12. Acute Myeloid Leukemia - p. 176 29. 13. Secondary Myeloid Neoplasms - p. 198 30. 14. Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions - p. 215 31. 15. Mastocytosis - p. 227 32. 16. Plasmacytoid Dendritic Cell Neoplasms - p. 236 33. Part 2: Lymphoid Neoplasms - p. 239 34. 17. Overview and Classification of Lymphoid Neoplasms - p. 240 35. 18. Precursor Lymphoid Neoplasms and Leukemias of Ambiguous Lineage - p. 249 36. 18.1 B-Lymphoblastic Leukemia/Lymphoma - p. 249 37. 18.2 T-Lymphoblastic Leukemia/Lymphoma - p. 258 38. 18.3 Acute Leukemias of Mixed or Ambiguous Lineage - p. 267 39. 19. Mature B-cell and Plasma Cell Neoplasms - p. 275 40. 19.1 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia - p. 275 41. 19.2 Extranodal, Nodal, and Pediatric Nodal Marginal Zone Lymphoma - p. 280 42. 19.3 Lymphoplasmacytic Lymphoma - p. 287 43. 19.4 Splenic B-Cell Leukemias/Lymphomas - p. 291 44. 19.5 Follicular Lymphoma - p. 300 45. 19.6 Mantle Cell Lymphoma - p. 309 46. 19.7 Large B-Cell Lymphomas - p. 314 47. 19.8 Burkitt Lymphoma - p. 338 48. 19.9 Kaposi Sarcoma Associated Herpes Virus (KSHV)/Human Herpesvirus 8 (HHV8) Associated B-Cell Proliferations and Lymphomas - p. 341 49. 19.10 Primary Cutaneous B-Cell Lymphoproliferative Disorders/Lymphomas - p. 350 50. 19.11 Plasma Cell Neoplasms and Other Diseases Associated With Paraproteins - p. 358 51. 20. Hodgkin Lymphomas - p. 378 52. 20.1 Nodular Lymphocyte-Predominant Hodgkin Lymphoma - p. 378 53. 20.2 Classic Hodgkin Lymphoma - p. 382 54. 21. Mature T/NK-cell Neoplasms - p. 387 55. 21.1 Mature T-/NK-Cell Leukemias - p. 387 56. 21.2 Intestinal T/NK-Cell Lymphoproliferative Disorders and Lymphomas - p. 402 57. 21.3 Hepatosplenic T-Cell Lymphoma - p. 415 58. 21.4 Epstein Bar Virus-Positive NK-/T-Cell Lymphomas - p. 417 59. 21.5 Anaplastic Large Cell Lymphomas - p. 423 60. 21.6 Primary Cutaneous T-Cell Lymphoproliferative Disorders/Lymphomas - p. 430 61. 21.7 Lymphomas of T Follicular Helper Cell Origin - p. 447 62. 21.8 Peripheral T-Cell Lymphoma, Not Otherwise Specified - p. 455 63. 21.9 Epstein Bar Virus-Positive NK-/T-Cell Lymphoproliferative Diseases of Childhood - p. 459 64. Part 3: Immunodeficiency-Associated Lymphoproliferative Disorders - p. 465 65. 22. Overview and Classification of Immunodeficiency-Associated Lymphoproliferative Disorders - p. 466 66. 23. Lymphoid Proliferations and Lymphomas Associated With Immune Deficiency/Dysregulation - p. 468 67. 24. Inborn Error of Immunity–Associated Lymphoid Proliferations and Lymphomas - p. 475 68. Part 4: Histiocytic and Dendritic Cell Neoplasms - p. 477 69. 25. Introduction to Histiocytic and Dendritic Cell Neoplasms - p. 478 70. 26. Histiocytic Sarcoma - p. 482 71. 27. Langerhans Cell Tumors - p. 485 72. 28. Juvenile Xanthogranuloma - p. 489 73. 29. Rosai-Dorfman Disease - p. 492 74. 30. Other Histiocytic/Dendritic Cell Neoplasms - p. 494 75. 30.1 Dendritic Cell and Dendritic Cell–Like Neoplasms - p. 494 76. 30.2 Erdheim-Chester Disease - p. 501 77. 30.3 ALK-Positive Histiocytosis - p. 503 78. IV Ancillary Techniques - p. 506 79. 31. Immunohistochemistry and Histochemistry - p. 507 80. 32. Flow Cytometry - p. 517 81. 33. Cytogenomics - p. 531 82. 34. Molecular Diagnostics - p. 546 83. 34.1 Interphase Fluorescence In Situ Hybridization - p. 546 84. 34.2 Polymerase Chain Reaction and Related Techniques - p. 553 85. 34.3 Next-Generation Sequencing - p. 566 86. Index - p. 585
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Continuing in the rich tradition of this popular handbook series, The Washington Manual® of Hematopathology provides concise, high-yield content that reflects today’s fast-changing advances in the field. Edited by Drs. Brooj Abro, John L. Frater, Louis P. Dehner, John D. Pfeifer, and Anjum Hassan, this all-new volume focuses on the essential information you need to know, using a concise format, along with numerous figures, tables, algorithms, and images throughout. In one convenient, portable resource, you’ll find complete coverage of hematopathology—both benign and malignant entities—all at your fingertips for quick review and reference.
1. I Introduction to Hematopathology - p. xii 2. 1. Normal Anatomy - p. 1 3. 1.1 Blood, Bone Marrow, and Thymus - p. 1 4. 1.2 Lymph Node - p. 10 5. 1.3 Spleen - p. 15 6. 2. Approach to the Bone Marrow and Lymph Node Biopsy - p. 18 7. 3. Approach to Fine Needle Aspiration of Hematologic Malignancies - p. 24 8. II Non-neoplastic - p. 31 9. 4. Peripheral blood - p. 32 10. 4.1: Red Blood Cell Disorders - p. 32 11. 4.2: White Blood Cell Disorders - p. 44 12. 4.3: Platelet Disorders - p. 53 13. 5. Bone marrow - p. 68 14. 5.1 Bone Marrow Abnormalities in Systemic Conditions - p. 68 15. 5.2 Bone Marrow Failure Syndromes - p. 77 16. 6. Lymph node - p. 84 17. 6.1: Reactive Lymphoid Hyperplasia and Benign Noninfectious Lymphadenopathies - p. 84 18. 6.2 Infectious Lymphadenopathies - p. 95 19. 7. Spleen - p. 107 20. 7.1 Nonneoplastic Disorders of the Spleen - p. 107 21. 7.2 Non-hematopoietic Tumors and Tumor-Like Lesions of the Spleen - p. 112 22. III Neoplastic - p. 115 23. Part 1: Myeloid Neoplasms - p. 115 24. 8. Overview and Classification of Myeloid Neoplasms - p. 116 25. 9. Myeloproliferative Neoplasms - p. 130 26. 10. Myeloid Precursor Lesions and Myelodysplastic Syndromes/Neoplasms - p. 149 27. 11. Myelodysplastic/Myeloproliferative Neoplasms - p. 164 28. 12. Acute Myeloid Leukemia - p. 176 29. 13. Secondary Myeloid Neoplasms - p. 198 30. 14. Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions - p. 215 31. 15. Mastocytosis - p. 227 32. 16. Plasmacytoid Dendritic Cell Neoplasms - p. 236 33. Part 2: Lymphoid Neoplasms - p. 239 34. 17. Overview and Classification of Lymphoid Neoplasms - p. 240 35. 18. Precursor Lymphoid Neoplasms and Leukemias of Ambiguous Lineage - p. 249 36. 18.1 B-Lymphoblastic Leukemia/Lymphoma - p. 249 37. 18.2 T-Lymphoblastic Leukemia/Lymphoma - p. 258 38. 18.3 Acute Leukemias of Mixed or Ambiguous Lineage - p. 267 39. 19. Mature B-cell and Plasma Cell Neoplasms - p. 275 40. 19.1 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia - p. 275 41. 19.2 Extranodal, Nodal, and Pediatric Nodal Marginal Zone Lymphoma - p. 280 42. 19.3 Lymphoplasmacytic Lymphoma - p. 287 43. 19.4 Splenic B-Cell Leukemias/Lymphomas - p. 291 44. 19.5 Follicular Lymphoma - p. 300 45. 19.6 Mantle Cell Lymphoma - p. 309 46. 19.7 Large B-Cell Lymphomas - p. 314 47. 19.8 Burkitt Lymphoma - p. 338 48. 19.9 Kaposi Sarcoma Associated Herpes Virus (KSHV)/Human Herpesvirus 8 (HHV8) Associated B-Cell Proliferations and Lymphomas - p. 341 49. 19.10 Primary Cutaneous B-Cell Lymphoproliferative Disorders/Lymphomas - p. 350 50. 19.11 Plasma Cell Neoplasms and Other Diseases Associated With Paraproteins - p. 358 51. 20. Hodgkin Lymphomas - p. 378 52. 20.1 Nodular Lymphocyte-Predominant Hodgkin Lymphoma - p. 378 53. 20.2 Classic Hodgkin Lymphoma - p. 382 54. 21. Mature T/NK-cell Neoplasms - p. 387 55. 21.1 Mature T-/NK-Cell Leukemias - p. 387 56. 21.2 Intestinal T/NK-Cell Lymphoproliferative Disorders and Lymphomas - p. 402 57. 21.3 Hepatosplenic T-Cell Lymphoma - p. 415 58. 21.4 Epstein Bar Virus-Positive NK-/T-Cell Lymphomas - p. 417 59. 21.5 Anaplastic Large Cell Lymphomas - p. 423 60. 21.6 Primary Cutaneous T-Cell Lymphoproliferative Disorders/Lymphomas - p. 430 61. 21.7 Lymphomas of T Follicular Helper Cell Origin - p. 447 62. 21.8 Peripheral T-Cell Lymphoma, Not Otherwise Specified - p. 455 63. 21.9 Epstein Bar Virus-Positive NK-/T-Cell Lymphoproliferative Diseases of Childhood - p. 459 64. Part 3: Immunodeficiency-Associated Lymphoproliferative Disorders - p. 465 65. 22. Overview and Classification of Immunodeficiency-Associated Lymphoproliferative Disorders - p. 466 66. 23. Lymphoid Proliferations and Lymphomas Associated With Immune Deficiency/Dysregulation - p. 468 67. 24. Inborn Error of Immunity–Associated Lymphoid Proliferations and Lymphomas - p. 475 68. Part 4: Histiocytic and Dendritic Cell Neoplasms - p. 477 69. 25. Introduction to Histiocytic and Dendritic Cell Neoplasms - p. 478 70. 26. Histiocytic Sarcoma - p. 482 71. 27. Langerhans Cell Tumors - p. 485 72. 28. Juvenile Xanthogranuloma - p. 489 73. 29. Rosai-Dorfman Disease - p. 492 74. 30. Other Histiocytic/Dendritic Cell Neoplasms - p. 494 75. 30.1 Dendritic Cell and Dendritic Cell–Like Neoplasms - p. 494 76. 30.2 Erdheim-Chester Disease - p. 501 77. 30.3 ALK-Positive Histiocytosis - p. 503 78. IV Ancillary Techniques - p. 506 79. 31. Immunohistochemistry and Histochemistry - p. 507 80. 32. Flow Cytometry - p. 517 81. 33. Cytogenomics - p. 531 82. 34. Molecular Diagnostics - p. 546 83. 34.1 Interphase Fluorescence In Situ Hybridization - p. 546 84. 34.2 Polymerase Chain Reaction and Related Techniques - p. 553 85. 34.3 Next-Generation Sequencing - p. 566 86. Index - p. 585
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