Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of contributors - p. xi 6. 1. PEGylated “stealth” nanoparticles and liposomes - p. 1 7. 2. The case for protein PEGylation - p. 27 8. 3. PEGylation and anti-PEG antibodies - p. 51 9. 4. Polyzwitterions - p. 69 10. 5. Polyglycerols - p. 103 11. 6. Poly(oxazolines) - p. 173 12. 7. Poly(amino acids) - p. 199 13. 8. Polyacrylamide and related polymers - p. 229 14. 9. Poly(vinylpyrrolidone) - p. 255 15. 10. Sugar-based systems - p. 273 16. 11. Polypeptides: PASylation and XTEN - p. 299 17. 12. Drug delivery systems based on nonimmunogenic biopolymers - p. 317 18. 13. Stealth coatings for nanoparticles: Polyethylene glycol alternatives - p. 345 19. 14. PEGylation and its alternatives: A summary - p. 363 20. Index - p. 377
Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of contributors - p. xi 6. 1. PEGylated “stealth” nanoparticles and liposomes - p. 1 7. 2. The case for protein PEGylation - p. 27 8. 3. PEGylation and anti-PEG antibodies - p. 51 9. 4. Polyzwitterions - p. 69 10. 5. Polyglycerols - p. 103 11. 6. Poly(oxazolines) - p. 173 12. 7. Poly(amino acids) - p. 199 13. 8. Polyacrylamide and related polymers - p. 229 14. 9. Poly(vinylpyrrolidone) - p. 255 15. 10. Sugar-based systems - p. 273 16. 11. Polypeptides: PASylation and XTEN - p. 299 17. 12. Drug delivery systems based on nonimmunogenic biopolymers - p. 317 18. 13. Stealth coatings for nanoparticles: Polyethylene glycol alternatives - p. 345 19. 14. PEGylation and its alternatives: A summary - p. 363 20. Index - p. 377
