Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research. Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.
1. Glycolysis - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Contents - p. Page vi 7. List of contributors - p. Page vii 8. Preface - p. Page vii 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Glycolysis: breaking paradigms since Meyerhof’s contribution - p. Page xi 12. Chapter 2 : Development and glycolysis dependence - p. Page 11 13. Chapter 3 : Neuro–glia communication and glycolysis - p. Page 23 14. Chapter 4 : Glycolysis and skeletal muscle plasticity: lactate as a key signaling molecule - p. Page 42 15. Chapter 5 : Glucose utilization by the trained heart: the molecular mechanisms behind fuel choice - p. Page 67 16. Chapter 6 : Bone glycolysis and the regulation of energy balance - p. Page 87 17. Chapter 7 : Glycolysis in adipose tissue-dependent thermogenesis - p. Page 111 18. Chapter 8 : Liver metabolism: the pathways underlying glucose utilization and production - p. Page 134 19. Chapter 9 : The Warburg-like effect in male reproductive events - p. Page 154 20. Chapter 10 : Pancreatic β cells: the metabolic network underlying body’s glucostat - p. Page 172 21. Chapter 11 : Exploring glycolytic adaptations in cancer cells - p. Page 194 22. Chapter 12 : The glycolytic pathway to heart failure - p. Page 225 23. Chapter 13 : Glycolysis in pulmonary arterial hypertension and metabolic reprogramming - p. Page 247 24. Chapter 14 : Glycolysis and diabetes mellitus - p. Page 283 25. Chapter 15 : Inborn glycolytic pathway defects - p. Page 311 26. Chapter 16 : Glucose, glycolysis, and neurodegenerative disorders - p. Page 329 27. Chapter 17 : Viral infections and glycolysis - p. Page 362 28. Chapter 18 : Useful bioinformatics approaches for studying pathological conditions characterized by the dysregulation of glucose metabolism - p. Page 404 29. Chapter 19 : Determination of glycolysis flux by extracellular flux measurements - p. Page 440 30. Index - p. Page 453
Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research. Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.
1. Glycolysis - p. Page i 2. Cover - p. Page i 3. Title page - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iii 6. Contents - p. Page vi 7. List of contributors - p. Page vii 8. Preface - p. Page vii 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Glycolysis: breaking paradigms since Meyerhof’s contribution - p. Page xi 12. Chapter 2 : Development and glycolysis dependence - p. Page 11 13. Chapter 3 : Neuro–glia communication and glycolysis - p. Page 23 14. Chapter 4 : Glycolysis and skeletal muscle plasticity: lactate as a key signaling molecule - p. Page 42 15. Chapter 5 : Glucose utilization by the trained heart: the molecular mechanisms behind fuel choice - p. Page 67 16. Chapter 6 : Bone glycolysis and the regulation of energy balance - p. Page 87 17. Chapter 7 : Glycolysis in adipose tissue-dependent thermogenesis - p. Page 111 18. Chapter 8 : Liver metabolism: the pathways underlying glucose utilization and production - p. Page 134 19. Chapter 9 : The Warburg-like effect in male reproductive events - p. Page 154 20. Chapter 10 : Pancreatic β cells: the metabolic network underlying body’s glucostat - p. Page 172 21. Chapter 11 : Exploring glycolytic adaptations in cancer cells - p. Page 194 22. Chapter 12 : The glycolytic pathway to heart failure - p. Page 225 23. Chapter 13 : Glycolysis in pulmonary arterial hypertension and metabolic reprogramming - p. Page 247 24. Chapter 14 : Glycolysis and diabetes mellitus - p. Page 283 25. Chapter 15 : Inborn glycolytic pathway defects - p. Page 311 26. Chapter 16 : Glucose, glycolysis, and neurodegenerative disorders - p. Page 329 27. Chapter 17 : Viral infections and glycolysis - p. Page 362 28. Chapter 18 : Useful bioinformatics approaches for studying pathological conditions characterized by the dysregulation of glucose metabolism - p. Page 404 29. Chapter 19 : Determination of glycolysis flux by extracellular flux measurements - p. Page 440 30. Index - p. Page 453
