Human Gonadotropins is a must-have reference for basic science researchers looking to maximize their knowledge in this specific field of study. Luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin are essential for reproduction and outlined in detail in this work, covering topics ranging from antibodies and immunoassays, to commercial products and standards, genetics, and receptors and intermediaries for gonadotropins. Dr. Laurence Cole has been recognized for his outstanding research throughout his illustrious career. He has received awards from the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. This detailed resource compiles all the recent research together into one volume, with one consistent voice.
1. Introduction - p. xi 2. Chapter 1 Evolution of LH and FSH from a common gonadotropic ancestral hormone - p. 1 3. Chapter 2 Evolution of CG and development of humans - p. 5 4. Chapter 3 Structure of FSH - p. 13 5. Chapter 4 Structure of LH - p. 17 6. Chapter 5 Structure of hCG - p. 21 7. Chapter 6 Structure of multiple forms of hCG - p. 27 8. Chapter 7 Synthesis of the gonadotropins - p. 37 9. Chapter 8 Function of gonadotropin releasing hormone and inhibin - p. 41 10. Chapter 9 Function of hormone hCG - p. 55 11. Chapter 10 Function of hyperglycosylated hCG and extravillous cytotrophoblast hCG - p. 65 12. Chapter 11 Degradation of hCG - p. 71 13. Chapter 12 Gonadotropin immunoassays: antibodies and standards for hCG, LH, and FSH - p. 75 14. Chapter 13 Genetics of the gonadotropins - p. 79 15. Chapter 14 Gonadotropins and steroidogenesis - p. 85 16. Chapter 15 Gonadotropins and female reproduction - p. 97 17. Chapter 16 Male reproduction: sperm formation and activation - p. 111 18. Chapter 17 Adrenarche and menarche in girls and adrenarche and puberty in boys - p. 123 19. Chapter 18 Function of the luteinizing hormone/chorionic gonadotropin receptor - p. 131 20. Chapter 19 Function of folllicle stimulating hormone and the follicle stimulating hormone receptor - p. 145 21. Chapter 20 Function of hCG and pregnancy - p. 159 22. Chapter 21 Pituitary sulfated hCG - p. 163 23. Chapter 22 Hyperglycosylated hCG and extravillous cytotrophoblast hCG - p. 165 24. Chapter 23 hCG and pregnancy tests - p. 173 25. Chapter 24 False-positive hCG pregnancy tests - p. 177 26. Chapter 25 Implantation and pregnancy failure - p. 189 27. Chapter 26 Deep implantation, hCG, gestational hypertension, and preeclampsia - p. 193 28. Chapter 27 hCG, gestational trophoblastic diseases, and choriocarcinoma - p. 197 29. Chapter 28 Ovarian cystic disorders - p. 203 30. Chapter 29 Illicit use of hCG in dietary programs and to promote anabolism - p. 207 31. Chapter 30 Cancer hCG, hyperglycosylated hCG, extravillous cytotrophoblastic hCG and TGFβ receptor 2 - p. 213 32. Chapter 31 hCG molecules produced in cancer inhibit apoptosis and cell death, a process which can be overturned by specific antibodies: paving a way towards targeted adjuvant cancer immunotherapy - p. 229 33. Abbreviations - p. 247 34. Index - p. 249
Human Gonadotropins is a must-have reference for basic science researchers looking to maximize their knowledge in this specific field of study. Luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin are essential for reproduction and outlined in detail in this work, covering topics ranging from antibodies and immunoassays, to commercial products and standards, genetics, and receptors and intermediaries for gonadotropins. Dr. Laurence Cole has been recognized for his outstanding research throughout his illustrious career. He has received awards from the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. This detailed resource compiles all the recent research together into one volume, with one consistent voice.
1. Introduction - p. xi 2. Chapter 1 Evolution of LH and FSH from a common gonadotropic ancestral hormone - p. 1 3. Chapter 2 Evolution of CG and development of humans - p. 5 4. Chapter 3 Structure of FSH - p. 13 5. Chapter 4 Structure of LH - p. 17 6. Chapter 5 Structure of hCG - p. 21 7. Chapter 6 Structure of multiple forms of hCG - p. 27 8. Chapter 7 Synthesis of the gonadotropins - p. 37 9. Chapter 8 Function of gonadotropin releasing hormone and inhibin - p. 41 10. Chapter 9 Function of hormone hCG - p. 55 11. Chapter 10 Function of hyperglycosylated hCG and extravillous cytotrophoblast hCG - p. 65 12. Chapter 11 Degradation of hCG - p. 71 13. Chapter 12 Gonadotropin immunoassays: antibodies and standards for hCG, LH, and FSH - p. 75 14. Chapter 13 Genetics of the gonadotropins - p. 79 15. Chapter 14 Gonadotropins and steroidogenesis - p. 85 16. Chapter 15 Gonadotropins and female reproduction - p. 97 17. Chapter 16 Male reproduction: sperm formation and activation - p. 111 18. Chapter 17 Adrenarche and menarche in girls and adrenarche and puberty in boys - p. 123 19. Chapter 18 Function of the luteinizing hormone/chorionic gonadotropin receptor - p. 131 20. Chapter 19 Function of folllicle stimulating hormone and the follicle stimulating hormone receptor - p. 145 21. Chapter 20 Function of hCG and pregnancy - p. 159 22. Chapter 21 Pituitary sulfated hCG - p. 163 23. Chapter 22 Hyperglycosylated hCG and extravillous cytotrophoblast hCG - p. 165 24. Chapter 23 hCG and pregnancy tests - p. 173 25. Chapter 24 False-positive hCG pregnancy tests - p. 177 26. Chapter 25 Implantation and pregnancy failure - p. 189 27. Chapter 26 Deep implantation, hCG, gestational hypertension, and preeclampsia - p. 193 28. Chapter 27 hCG, gestational trophoblastic diseases, and choriocarcinoma - p. 197 29. Chapter 28 Ovarian cystic disorders - p. 203 30. Chapter 29 Illicit use of hCG in dietary programs and to promote anabolism - p. 207 31. Chapter 30 Cancer hCG, hyperglycosylated hCG, extravillous cytotrophoblastic hCG and TGFβ receptor 2 - p. 213 32. Chapter 31 hCG molecules produced in cancer inhibit apoptosis and cell death, a process which can be overturned by specific antibodies: paving a way towards targeted adjuvant cancer immunotherapy - p. 229 33. Abbreviations - p. 247 34. Index - p. 249
