Narcolepsy: Integrating Basic and Clinical Knowledge provides comprehensive coverage of narcolepsy-related topics. The book offers updated, deep coverage of its diagnosis, treatment, and impact on mental health based on the latest research findings and clinical practices. Its interdisciplinary approach brings together experts from different specialties, such as sleep medicine, psychology, and neurology to offer a more holistic understanding. This allows for a more nuanced discussion of how narcolepsy interacts with various aspects of health and well-being. Researchers and clinicians will find within this book novel information on pathophysiology and neurobiology, as well as behavioral and psychosocial considerations.
Users will find this to be a resource that takes a deep dive into narcolepsy, introducing topics never before discussed in books on the topic, including COVID-19 and sleep, as well as immunotherapy and gene therapy. It’s the cutting-edge medical volume professionals need, whether narcolepsy specialists or more casual readers.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xxiii 7. About the editors - p. xxix 8. Foreword - p. xxxi 9. Preface - p. xxxiii 10. Acknowledgments - p. xxxvii 11. Part I: Pathophysiology and neurobiology - p. 1 12. Chapter 1. Understanding sleep in narcolepsy: sleep physiology, neurobiology, and cognitive impairment mechanisms - p. 3 13. Chapter 2. Pathophysiology of narcolepsy: genetics and immune system - p. 27 14. Chapter 3. Neurotransmitters, genetics, and animal models in narcolepsy: a comprehensive overview - p. 41 15. Chapter 4. The gut–brain axis in narcolepsy: emerging research on microbiota, diet, and sleep - p. 79 16. Part II: Clinical aspects - p. 91 17. Chapter 5. Types of narcolepsy and their symptoms: differential diagnosis and misdiagnosis - p. 93 18. Chapter 6. Delayed diagnosis of narcolepsy: causes and implications - p. 101 19. Chapter 7. Diagnostic tools for narcolepsy: sleep studies, multiple sleep latency test, and more - p. 119 20. Chapter 8. Narcolepsy in children and adolescents: diagnosis, management, and challenges - p. 147 21. Chapter 9. Narcolepsy and pregnancy: risks and strategies for management - p. 161 22. Chapter 10. Aging with narcolepsy: understanding the unique challenges for older adults - p. 173 23. Chapter 11. Medical comorbidities of narcolepsy - p. 195 24. Chapter 12. Cardiovascular disease risk and comorbidities in narcolepsy - p. 221 25. Chapter 13. More than just narcolepsy: the importance of recognizing concurrent sleep disorders - p. 235 26. Chapter 14. Narcolepsy and circadian rhythm disorders: diagnosis and management - p. 251 27. Chapter 15. The hidden link between narcolepsy and autonomic dysfunction: a closer look - p. 265 28. Chapter 16. Narcolepsy and metabolic rate: what do we know? - p. 281 29. Chapter 17. Narcolepsy and driving: safety issues and regulations - p. 305 30. Chapter 18. The natural history of narcolepsy: lessons from longitudinal studies - p. 319 31. Chapter 19. Neuroimaging in narcolepsy: advances in understanding pathophysiology and diagnosis - p. 343 32. Chapter 20. The distinctive characteristics of REM sleep and dreams in narcolepsy - p. 361 33. Part III: Behavioral and psychosocial considerations - p. 385 34. Chapter 21. The hidden burden of narcolepsy: anxiety and depression among patients - p. 387 35. Chapter 22. Understanding psychosis and behavioral abnormalities in narcolepsy patients - p. 407 36. Chapter 23. Narcolepsy and cognitive impairment - p. 437 37. Chapter 24. Narcolepsy and relationships: navigating intimacy, family, and social life - p. 451 38. Chapter 25. Narcolepsy and advocacy: awareness, education, and community building - p. 459 39. Chapter 26. The complexities of medico-legal assessment of disability in narcolepsy - p. 471 40. Part IV: Specific management and future directions - p. 485 41. Chapter 27. Current pharmacological treatments for narcolepsy - p. 487 42. Chapter 28. Exploring the potential of psychotherapy and cognitive behavioral therapy as an adjunct to medication in narcolepsy management - p. 505 43. Chapter 29. Emerging therapies for narcolepsy: immunotherapy, gene therapy, and beyond - p. 535 44. Chapter 30. Exploring the role of biomarkers and epigenetics in narcolepsy: implications for diagnosis and treatment - p. 563 45. Chapter 31. Telehealth for care of narcolepsy - p. 583 46. Chapter 32. The future of narcolepsy treatment: what role will artificial intelligence play? - p. 597 47. Chapter 33. Narcolepsy and chronic pain: implications and management - p. 621 48. Chapter 34. Navigating the costs of narcolepsy in managed care - p. 629 49. Index - p. 637
Narcolepsy: Integrating Basic and Clinical Knowledge provides comprehensive coverage of narcolepsy-related topics. The book offers updated, deep coverage of its diagnosis, treatment, and impact on mental health based on the latest research findings and clinical practices. Its interdisciplinary approach brings together experts from different specialties, such as sleep medicine, psychology, and neurology to offer a more holistic understanding. This allows for a more nuanced discussion of how narcolepsy interacts with various aspects of health and well-being. Researchers and clinicians will find within this book novel information on pathophysiology and neurobiology, as well as behavioral and psychosocial considerations.
Users will find this to be a resource that takes a deep dive into narcolepsy, introducing topics never before discussed in books on the topic, including COVID-19 and sleep, as well as immunotherapy and gene therapy. It’s the cutting-edge medical volume professionals need, whether narcolepsy specialists or more casual readers.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xxiii 7. About the editors - p. xxix 8. Foreword - p. xxxi 9. Preface - p. xxxiii 10. Acknowledgments - p. xxxvii 11. Part I: Pathophysiology and neurobiology - p. 1 12. Chapter 1. Understanding sleep in narcolepsy: sleep physiology, neurobiology, and cognitive impairment mechanisms - p. 3 13. Chapter 2. Pathophysiology of narcolepsy: genetics and immune system - p. 27 14. Chapter 3. Neurotransmitters, genetics, and animal models in narcolepsy: a comprehensive overview - p. 41 15. Chapter 4. The gut–brain axis in narcolepsy: emerging research on microbiota, diet, and sleep - p. 79 16. Part II: Clinical aspects - p. 91 17. Chapter 5. Types of narcolepsy and their symptoms: differential diagnosis and misdiagnosis - p. 93 18. Chapter 6. Delayed diagnosis of narcolepsy: causes and implications - p. 101 19. Chapter 7. Diagnostic tools for narcolepsy: sleep studies, multiple sleep latency test, and more - p. 119 20. Chapter 8. Narcolepsy in children and adolescents: diagnosis, management, and challenges - p. 147 21. Chapter 9. Narcolepsy and pregnancy: risks and strategies for management - p. 161 22. Chapter 10. Aging with narcolepsy: understanding the unique challenges for older adults - p. 173 23. Chapter 11. Medical comorbidities of narcolepsy - p. 195 24. Chapter 12. Cardiovascular disease risk and comorbidities in narcolepsy - p. 221 25. Chapter 13. More than just narcolepsy: the importance of recognizing concurrent sleep disorders - p. 235 26. Chapter 14. Narcolepsy and circadian rhythm disorders: diagnosis and management - p. 251 27. Chapter 15. The hidden link between narcolepsy and autonomic dysfunction: a closer look - p. 265 28. Chapter 16. Narcolepsy and metabolic rate: what do we know? - p. 281 29. Chapter 17. Narcolepsy and driving: safety issues and regulations - p. 305 30. Chapter 18. The natural history of narcolepsy: lessons from longitudinal studies - p. 319 31. Chapter 19. Neuroimaging in narcolepsy: advances in understanding pathophysiology and diagnosis - p. 343 32. Chapter 20. The distinctive characteristics of REM sleep and dreams in narcolepsy - p. 361 33. Part III: Behavioral and psychosocial considerations - p. 385 34. Chapter 21. The hidden burden of narcolepsy: anxiety and depression among patients - p. 387 35. Chapter 22. Understanding psychosis and behavioral abnormalities in narcolepsy patients - p. 407 36. Chapter 23. Narcolepsy and cognitive impairment - p. 437 37. Chapter 24. Narcolepsy and relationships: navigating intimacy, family, and social life - p. 451 38. Chapter 25. Narcolepsy and advocacy: awareness, education, and community building - p. 459 39. Chapter 26. The complexities of medico-legal assessment of disability in narcolepsy - p. 471 40. Part IV: Specific management and future directions - p. 485 41. Chapter 27. Current pharmacological treatments for narcolepsy - p. 487 42. Chapter 28. Exploring the potential of psychotherapy and cognitive behavioral therapy as an adjunct to medication in narcolepsy management - p. 505 43. Chapter 29. Emerging therapies for narcolepsy: immunotherapy, gene therapy, and beyond - p. 535 44. Chapter 30. Exploring the role of biomarkers and epigenetics in narcolepsy: implications for diagnosis and treatment - p. 563 45. Chapter 31. Telehealth for care of narcolepsy - p. 583 46. Chapter 32. The future of narcolepsy treatment: what role will artificial intelligence play? - p. 597 47. Chapter 33. Narcolepsy and chronic pain: implications and management - p. 621 48. Chapter 34. Navigating the costs of narcolepsy in managed care - p. 629 49. Index - p. 637
