For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized.
Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis.
Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples.
1. Brief Table of Contents 2. Table of Contents 3. Copyright Page 4. Preface 5. List of Contributors 6. List of Editors 7. Part I. Fundamentals and Techniques 8. Chapter 1. Principles in NMR Spectroscopy 9. Chapter 2. Quantitative NMR in the Solution State NMR 10. Chapter 3. qNMR in Solid State 11. Chapter 4. Microcoil Nuclear Magnetic Resonance Spectroscopy 12. Chapter 5. qNMR Spectroscopy in Drug Analysis – A General View 13. Part II. General Applications 14. Chapter 1. Investigation of Multi-Component Drugs by NMR Spectroscopy 15. Chapter 2. NMR Applications for Polymer Characterisation 16. Chapter 3. NMR Spectroscopy of Natural Substances 17. Chapter 4. Solid-State Measurements of Drugs and Drug Formulations 18. Chapter 5. Metabolic Profiling 19. Chapter 6. DOSY NMR for Drug Analysis 20. Chapter 7. The Use of qNMR for the Analysis of Agrochemicals 21. Part III. Special Applications 22. Chapter 1. NMR-Based Mixture Analysis on the Example of Fruit Juice Quality Control Using Statistics and Quantification 23. Chapter 2. NMR Assays for Carbohydrate-Based Vaccines 24. Chapter 3. Fluorine-19 or Phosphorus-31 NMR Spectroscopy 25. Chapter 4. Quantitative 2D NMR Analysis of Glycosaminoglycans 26. Chapter 5. The Use of Proton NMR as an Alternative for the Amino Acid Analysis as Identity Test for Peptides 27. Chapter 6. Assessment of the Inhibitory Potency of Antibiotics by MRI 28. Chapter 7. Hypernation and Concatenation 29. Chapter 8. Quantitative High-Resolution Online NMR Spectroscopy in Pharmaceutical Reaction and Process Monitoring
For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized.
Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis.
Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples.
1. Brief Table of Contents 2. Table of Contents 3. Copyright Page 4. Preface 5. List of Contributors 6. List of Editors 7. Part I. Fundamentals and Techniques 8. Chapter 1. Principles in NMR Spectroscopy 9. Chapter 2. Quantitative NMR in the Solution State NMR 10. Chapter 3. qNMR in Solid State 11. Chapter 4. Microcoil Nuclear Magnetic Resonance Spectroscopy 12. Chapter 5. qNMR Spectroscopy in Drug Analysis – A General View 13. Part II. General Applications 14. Chapter 1. Investigation of Multi-Component Drugs by NMR Spectroscopy 15. Chapter 2. NMR Applications for Polymer Characterisation 16. Chapter 3. NMR Spectroscopy of Natural Substances 17. Chapter 4. Solid-State Measurements of Drugs and Drug Formulations 18. Chapter 5. Metabolic Profiling 19. Chapter 6. DOSY NMR for Drug Analysis 20. Chapter 7. The Use of qNMR for the Analysis of Agrochemicals 21. Part III. Special Applications 22. Chapter 1. NMR-Based Mixture Analysis on the Example of Fruit Juice Quality Control Using Statistics and Quantification 23. Chapter 2. NMR Assays for Carbohydrate-Based Vaccines 24. Chapter 3. Fluorine-19 or Phosphorus-31 NMR Spectroscopy 25. Chapter 4. Quantitative 2D NMR Analysis of Glycosaminoglycans 26. Chapter 5. The Use of Proton NMR as an Alternative for the Amino Acid Analysis as Identity Test for Peptides 27. Chapter 6. Assessment of the Inhibitory Potency of Antibiotics by MRI 28. Chapter 7. Hypernation and Concatenation 29. Chapter 8. Quantitative High-Resolution Online NMR Spectroscopy in Pharmaceutical Reaction and Process Monitoring
