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Part of the popular Orthopaedic Knowledge Update® series, this comprehensive orthopaedic resource covers all aspects of the latest innovations in tumor care and optimized treatment in a single, convenient volume. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Geoffrey W. Siegel, MD, FAAOS, and J. Sybil Biermann, MD, FAAOS, Orthopaedic Knowledge Update®: Musculoskeletal Tumors 5 reflects cutting-edge research and understanding of the molecular basis of neoplastic disease and optimized treatment options since the last volume published in 2020. Written and edited by leading orthopaedic surgeons and specialists, OKU®: Musculoskeletal Tumors 5 provides deep insight, real-world patient scenarios, and best practices supported by the latest evidence.

1. Cover image - p. i 2. Title page - p. iii 3. Copyright - p. iv 4. Acknowledgments - p. v 5. Contributors - p. vi 6. Preface - p. xi 7. Table of Contents - p. xiii 8. Section 1: General Evaluation and Treatment of Musculoskeletal Tumors - p. 1 9. Chapter 1. Evaluation of Bone Tumors - p. 3 10. Chapter 2. Evaluation of Soft-Tissue Tumors - p. 15 11. Chapter 3. Biopsy - p. 25 12. Chapter 4. Molecular Biology in the Pathogenesis of Musculoskeletal Neoplasia - p. 33 13. Chapter 5. Molecular Biology in the Clinical Management of Musculoskeletal Neoplasia - p. 47 14. Chapter 6. Tumorlike Lesions of Soft Tissue - p. 63 15. Chapter 7. Pseudotumors and Tumorlike Lesions of Bone - p. 79 16. Chapter 8. Systemic Treatment of Bone Sarcoma - p. 89 17. Chapter 9. Systemic Treatments for Soft-Tissue Sarcoma - p. 101 18. Chapter 10. Radiation Therapy - p. 111 19. Section 2: Benign Bone Tumors - p. 125 20. Chapter 11. Benign Radiolucent Lesions - p. 127 21. Chapter 12. Benign Cartilage Lesions - p. 141 22. Chapter 13. Benign Bone-Forming Tumors - p. 155 23. Chapter 14. Benign Fibrous Lesions and Langerhans Cell Histiocytosis - p. 169 24. Chapter 15. Giant Cell Tumor of Bone - p. 179 25. Section 3: Malignant Primary Bone Tumors - p. 193 26. Chapter 16. Conventional Osteoblastic Osteosarcoma - p. 195 27. Chapter 17. Osteosarcoma Variants - p. 207 28. Chapter 18. Ewing Sarcoma and Other Undifferentiated Small Round Cell Sarcomas - p. 217 29. Chapter 19. Chondrosarcoma of Bone - p. 227 30. Chapter 20. Miscellaneous Malignant Primary Bone Tumors - p. 241 31. Chapter 21. Multiple Myeloma - p. 251 32. Chapter 22. Lymphoma - p. 265 33. Section 4: Soft-Tissue Tumors - p. 275 34. Chapter 23. Benign Vascular Soft-Tissue Tumors - p. 277 35. Chapter 24. Benign Cystic Soft-Tissue Lesions - p. 287 36. Chapter 25. Lipoma and Other Benign Lipomatous Tumors - p. 303 37. Chapter 26. Benign Neural Tumors - p. 311 38. Chapter 27. Benign Fibrous Tumors - p. 325 39. Chapter 28. Tenosynovial Giant Cell Tumor and Synovial Chondromatosis - p. 333 40. Chapter 29. Miscellaneous Benign Soft-Tissue Tumors - p. 341 41. Chapter 30. Soft-Tissue Sarcomas - p. 353 42. Chapter 31. Treatment of Soft-Tissue Sarcomas - p. 367 43. Section 5: Metabolic Disease to Bone - p. 379 44. Chapter 32. The Pathophysiology of Bone Metastasis - p. 381 45. Chapter 33. Approach to the Patient With Bone Metastasis - p. 393 46. Chapter 34. Surgical Management of Upper Extremity Bone Metastases: A Treatment Algorithm - p. 407 47. Chapter 35. Surgical Management of Lower Extremity Metastatic Disease - p. 415 48. Chapter 36. Evaluation and Management of Spinal Metastases - p. 425 49. Section 6: Treatment of Bone Tumors - p. 437 50. Chapter 37. General Principles of Intralesional Treatment of Bone Tumors - p. 439 51. Chapter 38. General Principles of Wide Resection of Bone Tumors - p. 453 52. Chapter 39. Pelvic Sarcoma Resection and Reconstruction - p. 469 53. Chapter 40. Proximal Femur Resection and Reconstruction - p. 481 54. Chapter 41. Distal Femoral Resection and Reconstruction - p. 487 55. Chapter 42. Proximal Tibial Resection and Reconstruction - p. 497 56. Chapter 43. Upper Extremity Resection and Reconstruction - p. 507 57. Chapter 44. Bone Grafting, Bone Graft Substitutes, and Growth Factors in Reconstruction for Bone Defects - p. 519 58. Chapter 45. Surgical Management of Sarcomas in Skeletally Immature Patients - p. 533 59. Chapter 46. Amputations - p. 555 60. Index - p. 569

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Part of the popular Orthopaedic Knowledge Update® series, this comprehensive orthopaedic resource covers all aspects of the latest innovations in tumor care and optimized treatment in a single, convenient volume. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Geoffrey W. Siegel, MD, FAAOS, and J. Sybil Biermann, MD, FAAOS, Orthopaedic Knowledge Update®: Musculoskeletal Tumors 5 reflects cutting-edge research and understanding of the molecular basis of neoplastic disease and optimized treatment options since the last volume published in 2020. Written and edited by leading orthopaedic surgeons and specialists, OKU®: Musculoskeletal Tumors 5 provides deep insight, real-world patient scenarios, and best practices supported by the latest evidence.

1. Cover image - p. i 2. Title page - p. iii 3. Copyright - p. iv 4. Acknowledgments - p. v 5. Contributors - p. vi 6. Preface - p. xi 7. Table of Contents - p. xiii 8. Section 1: General Evaluation and Treatment of Musculoskeletal Tumors - p. 1 9. Chapter 1. Evaluation of Bone Tumors - p. 3 10. Chapter 2. Evaluation of Soft-Tissue Tumors - p. 15 11. Chapter 3. Biopsy - p. 25 12. Chapter 4. Molecular Biology in the Pathogenesis of Musculoskeletal Neoplasia - p. 33 13. Chapter 5. Molecular Biology in the Clinical Management of Musculoskeletal Neoplasia - p. 47 14. Chapter 6. Tumorlike Lesions of Soft Tissue - p. 63 15. Chapter 7. Pseudotumors and Tumorlike Lesions of Bone - p. 79 16. Chapter 8. Systemic Treatment of Bone Sarcoma - p. 89 17. Chapter 9. Systemic Treatments for Soft-Tissue Sarcoma - p. 101 18. Chapter 10. Radiation Therapy - p. 111 19. Section 2: Benign Bone Tumors - p. 125 20. Chapter 11. Benign Radiolucent Lesions - p. 127 21. Chapter 12. Benign Cartilage Lesions - p. 141 22. Chapter 13. Benign Bone-Forming Tumors - p. 155 23. Chapter 14. Benign Fibrous Lesions and Langerhans Cell Histiocytosis - p. 169 24. Chapter 15. Giant Cell Tumor of Bone - p. 179 25. Section 3: Malignant Primary Bone Tumors - p. 193 26. Chapter 16. Conventional Osteoblastic Osteosarcoma - p. 195 27. Chapter 17. Osteosarcoma Variants - p. 207 28. Chapter 18. Ewing Sarcoma and Other Undifferentiated Small Round Cell Sarcomas - p. 217 29. Chapter 19. Chondrosarcoma of Bone - p. 227 30. Chapter 20. Miscellaneous Malignant Primary Bone Tumors - p. 241 31. Chapter 21. Multiple Myeloma - p. 251 32. Chapter 22. Lymphoma - p. 265 33. Section 4: Soft-Tissue Tumors - p. 275 34. Chapter 23. Benign Vascular Soft-Tissue Tumors - p. 277 35. Chapter 24. Benign Cystic Soft-Tissue Lesions - p. 287 36. Chapter 25. Lipoma and Other Benign Lipomatous Tumors - p. 303 37. Chapter 26. Benign Neural Tumors - p. 311 38. Chapter 27. Benign Fibrous Tumors - p. 325 39. Chapter 28. Tenosynovial Giant Cell Tumor and Synovial Chondromatosis - p. 333 40. Chapter 29. Miscellaneous Benign Soft-Tissue Tumors - p. 341 41. Chapter 30. Soft-Tissue Sarcomas - p. 353 42. Chapter 31. Treatment of Soft-Tissue Sarcomas - p. 367 43. Section 5: Metabolic Disease to Bone - p. 379 44. Chapter 32. The Pathophysiology of Bone Metastasis - p. 381 45. Chapter 33. Approach to the Patient With Bone Metastasis - p. 393 46. Chapter 34. Surgical Management of Upper Extremity Bone Metastases: A Treatment Algorithm - p. 407 47. Chapter 35. Surgical Management of Lower Extremity Metastatic Disease - p. 415 48. Chapter 36. Evaluation and Management of Spinal Metastases - p. 425 49. Section 6: Treatment of Bone Tumors - p. 437 50. Chapter 37. General Principles of Intralesional Treatment of Bone Tumors - p. 439 51. Chapter 38. General Principles of Wide Resection of Bone Tumors - p. 453 52. Chapter 39. Pelvic Sarcoma Resection and Reconstruction - p. 469 53. Chapter 40. Proximal Femur Resection and Reconstruction - p. 481 54. Chapter 41. Distal Femoral Resection and Reconstruction - p. 487 55. Chapter 42. Proximal Tibial Resection and Reconstruction - p. 497 56. Chapter 43. Upper Extremity Resection and Reconstruction - p. 507 57. Chapter 44. Bone Grafting, Bone Graft Substitutes, and Growth Factors in Reconstruction for Bone Defects - p. 519 58. Chapter 45. Surgical Management of Sarcomas in Skeletally Immature Patients - p. 533 59. Chapter 46. Amputations - p. 555 60. Index - p. 569

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