**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**
Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues.
Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xv 8. About the editors - p. xxi 9. Preface - p. xxv 10. Chapter 1. Genomics and psychiatry: a historical overview - p. 1 11. Chapter 2. Schizophrenia genomics - p. 17 12. Chapter 3. Genetics of bipolar disorder - p. 43 13. Chapter 4. Genetics of depression - p. 63 14. Chapter 5. Genetics of personality disorders - p. 67 15. Chapter 6. Genomics and epigenomics of anxiety and obsessive-compulsive disorders - p. 85 16. Chapter 7. Neurogenetics of alcohol use disorder a subset of reward deficiency syndrome: candidate genes to be or not to be? - p. 105 17. Chapter 8. Pharmacogenomics and antipsychotics: efficacy and adverse drug reactions - p. 161 18. Chapter 9. Pharmacogenomics and antidepressants: efficacy and adverse drug reactions - p. 189 19. Chapter 10. Pharmacogenomics and mood stabilizers: efficacy and adverse drug reactions - p. 203 20. Chapter 11. Balancing prevention and respect: the ethical stakes of a psychiatric genomics lens for mental disorder and intellectual disability - p. 223 21. Chapter 12. Genetic animal models for psychiatric disorders - p. 241 22. Chapter 13. Psychiatric genomics: brain pathophysiology and genetic factors - p. 269 23. Chapter 14. Integration with systems biology approaches and -omics data to characterize risk variation - p. 289 24. Chapter 15. Usage of biobank data for psychiatric genomics and promotion of precision psychiatry - p. 317 25. Chapter 16. Shared heritability among psychiatric disorders and traits - p. 341 26. Chapter 17. Endophenotypes in psychiatric genomics: a selective review of their status and a call to action - p. 361 27. Index - p. 385
**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**
Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues.
Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xv 8. About the editors - p. xxi 9. Preface - p. xxv 10. Chapter 1. Genomics and psychiatry: a historical overview - p. 1 11. Chapter 2. Schizophrenia genomics - p. 17 12. Chapter 3. Genetics of bipolar disorder - p. 43 13. Chapter 4. Genetics of depression - p. 63 14. Chapter 5. Genetics of personality disorders - p. 67 15. Chapter 6. Genomics and epigenomics of anxiety and obsessive-compulsive disorders - p. 85 16. Chapter 7. Neurogenetics of alcohol use disorder a subset of reward deficiency syndrome: candidate genes to be or not to be? - p. 105 17. Chapter 8. Pharmacogenomics and antipsychotics: efficacy and adverse drug reactions - p. 161 18. Chapter 9. Pharmacogenomics and antidepressants: efficacy and adverse drug reactions - p. 189 19. Chapter 10. Pharmacogenomics and mood stabilizers: efficacy and adverse drug reactions - p. 203 20. Chapter 11. Balancing prevention and respect: the ethical stakes of a psychiatric genomics lens for mental disorder and intellectual disability - p. 223 21. Chapter 12. Genetic animal models for psychiatric disorders - p. 241 22. Chapter 13. Psychiatric genomics: brain pathophysiology and genetic factors - p. 269 23. Chapter 14. Integration with systems biology approaches and -omics data to characterize risk variation - p. 289 24. Chapter 15. Usage of biobank data for psychiatric genomics and promotion of precision psychiatry - p. 317 25. Chapter 16. Shared heritability among psychiatric disorders and traits - p. 341 26. Chapter 17. Endophenotypes in psychiatric genomics: a selective review of their status and a call to action - p. 361 27. Index - p. 385
